The Role of LINE-1 in the Death of a Fetal Oocyte

Fetal oocyte attrition is a poorly understood process in which approximately 80% of meiotic prophase I oocytes are eliminated through apoptotic pathways before birth. However, the primary triggers of fetal oocyte attrition are unknown. One hypothesis that has been proposed to explain this phenomenon is called “death by defect” which suggests that defective oocytes are preferentially eliminated in an effort to retain competent oocytes for the formation of primordial follicles.